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Gaboxadol (hydrochloride)
CAS No. 85118-33-8
Gaboxadol (hydrochloride) ( Lu 02-030 (hydrochloride) | THIP (hydrochloride) )
产品货号. M21075 CAS No. 85118-33-8
Gaboxadol (盐酸盐) 是一种 GABAA 受体激动剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥2152 | 有现货 |
|
| 10MG | ￥3237 | 有现货 |
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| 25MG | ￥5830 | 有现货 |
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| 50MG | ￥8732 | 有现货 |
|
| 100MG | 获取报价 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Gaboxadol (hydrochloride)
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Gaboxadol (盐酸盐) 是一种 GABAA 受体激动剂。
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产品描述Gaboxadol (hydrochloride) is a GABAA receptor agonist.(In Vitro):Gaboxadol hydrochloride (0.34, 3.5 and 7.0 μM) decreses permeability across Caco-2 cell monolayers with a dose dependent manner, shows the mean Papp values with 8.1 × 10-6 cm·s-1, 6.1 × 10-1 cm·s-6 and 5.6 × 10-6 cm·s-1 for 0.34, 3.5 and 7 μM gaboxadol, respectively.(In Vivo):Gaboxadol hydrochloride (intraperitoneal injection; 0.5, 1, 1.5, 2, 3, 4, or 5 mg/kg; once daily; three-day interval) normalizes the distance traveled by Fmr1 KO2 mice to WT activity levels at 0.5 mg/kg, additionally, this compound has no effect on locomotor activity in Fmr1 KO2 mice.
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体外实验Gaboxadol hydrochloride (0.34, 3.5 and 7.0 μM) decreses permeability across Caco-2 cell monolayers with a dose dependent manner, shows the mean Papp values with8.1 × 10-6 cm·s-1, 6.1 × 10-1 cm·s-6 and 5.6 × 10-6 cm·s-1 for 0.34, 3.5 and 7 μM gaboxadol, respectively.
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体内实验Gaboxadol hydrochloride (intraperitoneal injection; 0.5, 1, 1.5, 2, 3, 4, or 5 mg/kg; once daily; three-day interval) normalizes the distance traveled by?Fmr1?KO2 mice to WT activity levels at 0.5?mg/kg, additionally, this compound has no effect on locomotor activity in?Fmr1?KO2 mice. Animal Model:Fmr1?KO2 mice (deletion of the promoter and first exon of?Fmr1?resulting in mRNA and protein null mice) Dosage:0.5, 1, 1.5, 2, 3, 4, or 5 mg/kg Administration:Intraperitoneal injection Result:Normalized Hyperactivity Observed in?Fmr1?KO2 mice.
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同义词Lu 02-030 (hydrochloride) | THIP (hydrochloride)
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通路Others
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靶点Other Targets
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受体GABA
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研究领域——
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适应症——
化学信息
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CAS Number85118-33-8
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分子量176.6
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分子式C6H9ClN2O2
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纯度>98% (HPLC)
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溶解度DMSO:75 mg/mL (424.69 mM)
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SMILESCl.O=c1[nH]oc2c1CCNC2
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Zanettini C Pressly J D Ibarra M H et al. Comparing the discriminative stimulus effects of modulators of GABAAreceptors containing α4-δ subunits with those of gaboxadol in rats[J]. Psychopharmacology 2016 233(10):2005-2013.
产品手册
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